EARLY AND NEXT-GENERATION KIT/PDGFRA KINASE INHIBITORS AND THE FUTURE OF TREATMENT FOR ADVANCED GASTROINTESTINAL STROMAL TUMOR

Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor

The graco ascent majority of gastrointestinal stromal tumors (GIST) harbor an activating mutation in either the KIT or PDGFRA receptor tyrosine kinases.Approval of imatinib, a KIT/PDGFRA tyrosine kinase inhibitor (TKI), meaningfully improved the treatment of advanced GIST.Other TKIs subsequently gained approval: sunitinib as a second-line therapy a

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Open operative treatment of chronic ankle instability

Category: Ankle Introduction/Purpose: Ankle sprains are one of the most common musculoskeletal injuries.Though most patients recover fully without intervention, shure blx2 h10 10-30% will develop chronic ankle instability and require conservative or surgical management.The aim of this article is to provide an evidence-based literature review and as

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Critical Genocide Studies and Mass Atrocity Prevention

Critical genocide studies has emerged as an important strand of scholarship devoted to interrogating the core assumptions of the field of genocide studies.Drawing john tory hair on these developments, this article outlines a critical approach to modern atrocity prevention that is self-reflective, dialectical, multivalent, and anti-teleological.Part

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